What is ON and OFF time?

What is ON/OFF Time Banner

What is ON and OFF time?

During a typical day, you experience ON and OFF time1

Icon representing a person walking next to an "on" switch.

ON time is when:

  • Your Parkinson’s disease (PD) symptoms are at a minimum
  • Your oral levodopa/carbidopa medication is working well
  • You’re moving and able to go about your day
Icon representing a person shaking next to an "off" switch.

OFF time (or OFF episodes) is when:

  • Your PD symptoms have re-emerged and are at or near their worst
  • Your oral levodopa/carbidopa medication isn’t working well
  • Symptoms like stiffness (rigitdity), freezing, shaking (tremor), slowness, cramping, difficulty moving, shuffling, low voice, and loss of facial expression re-emerge

What is GOOD ON time?

GOOD ON time is ON time when you don't experience troublesome dyskinesia. As you experience diminishing benefits of levodopa/carbidopa over time, it's important to have GOOD ON time each day.1-3

OFF time

ON time

with troublesome  
dyskinesia

GOOD ON time

without troublesome  
dyskinesia

  • Troublesome dyskinesia is when uncontrollable (involuntary), abnormal movements interfere with your daily activities—even during ON time4
  • These abnormal movements often occur as a side effect of long-term treatment with levodopa/carbidopa5
  • Examples of dyskinesia include fidgeting, writhing and wriggling, head bobbing, and body swaying6

As you experience diminishing benefits of levodopa/carbidopa over time,
it's important to have GOOD ON time each day

What does your day with PD look like?

Now that you know more about ON time and OFF time, let’s see how well your current PD medication(s) are working for you throughout the day. XADAGO can increase your daily ON time without troublesome dyskinesia and can help reduce your OFF time.7

How do you feel throughout your day? Waking up, midmorning, midday, afternoon, early evening, bedtime.

If you’ve felt OFF at any time above, talk to your doctor to see if XADAGO can help increase your daily ON time without troublesome dyskinesia.

NEXT: Why XADAGO?

Pay as little as $15* on your
next XADAGO prescription LEARN MORE

*Patients whose prescriptions will be paid for in part or in whole by Medicare, Medicaid, or any similar federal or state healthcare program, are not eligible for savings or rebates according to federal and state law.
The actual savings on your out-of-pocket costs for XADAGO will vary according to refill quantity, personal healthcare insurance coverage, and adherence to FDA dosing guidelines.

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Do not take XADAGO if you:

  • Take another medicine called monoamine oxidase inhibitors (MAOIs), as it could cause a sudden severe increase in your blood pressure.
  • Take an opioid drug, St. John’s wort, serotonin‐norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants, cyclobenzaprine, methylphenidate, amphetamine, or similar drugs because it could be life‐threatening.
  • Take a medicine used to treat a cough or cold called dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior.
  • Have a history of an allergic reaction to safinamide, as this can cause swelling of the tongue and mouth and trouble breathing.
  • Have severe liver disease. Do not exceed a dose of 50mg per day of XADAGO if you have moderate liver disease.

Before taking XADAGO, tell your healthcare provider about: All the medicines that you take or plan to take. Especially tell your healthcare provider if you take selective serotonin reuptake inhibitors (SSRIs), meperidine, methadone, propoxyphene, tramadol, or metoclopramide.

While taking XADAGO you should avoid: Certain foods and beverages that are high in tyramine such as aged, fermented, cured, smoked, and pickled foods. Do not drive, operate machinery, or work in high places or do other dangerous activities until you know how XADAGO affects you.

Possible serious side effects of XADAGO:

  • High blood pressure or make your high blood pressure worse. XADAGO may raise your blood pressure or make your high blood pressure worse. Possible symptoms of an unsafe rise in blood pressure include severe headache, blurred vision, confusion, seizures, shortness of breath, severe anxiety, and nausea and vomiting.
  • Serotonin syndrome. Potentially life‐threatening problem called serotonin syndrome can happen when taking XADAGO with certain other medicines. Symptoms may include agitation, hallucinations, coma, changes in mental status, seizures, problems controlling your movements or muscle twitching, sweating or fever, nausea or vomiting, fast heartbeat, muscle stiffness or tightness, or diarrhea.
  • Falling asleep during normal activities.
  • Uncontrolled, sudden movements (dyskinesia) or make such movements worse.
  • Hallucinations and other psychosis. XADAGO can cause or worsen symptoms of seeing or hearing things that are not real, confusion, agitation, delusional beliefs, and disorganized thinking.
  • Unusual urges or inability to control these urges.
  • Problems with retina in your eye (retinal changes). Tell your healthcare provider if your eyesight changes.

The most common side effects of XADAGO include:

Uncontrolled, sudden movements (dyskinesia), falls, nausea, trouble sleeping or falling asleep.

Please refer to the Medication Guide for additional important patient information.

INDICATION

  • XADAGO is a prescription medicine known as a monoamine oxidase type B (MAO‐B) inhibitor used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Please see full Prescribing Information and Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

References
1. Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 2017;74(2):216-224. 2. Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Mov Disord. 2014;29(2):229-237. 3. Jankovic J. Motor fluctuations and dyskinesias in Parkinson’s disease: clinical manifestations. Mov Disord. 2005;20(Suppl 11)S11-S16. 4. U.S. Department of Health and Human Services, National Institutes of Health, National Institutes of Neurological Disorders and Stroke. Parkinson’s Disease: Hope Through Research. 2014. NIH Publication No. 15-139. Accessed May 8, 2017. 5. Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson’s disease. Neurology. 2009;72(Suppl 4)S1-S136. 6. Dyskinesia. The Michael J. Fox Foundation (MJFF) For Parkinson’s Research. Parkinson’s Support Groups. 2017. https://www.michaeljfox.org/understanding-parkinsons/living-with-pd/t opic.php?support-groups. Accessed May 8, 2017. 7. Borgohain R, Szasz J, Stanzione P, et al. Two-Year, Randomized, Controlled Study of Safinamide as Add-on to Levodopa in Mid to Late Parkinson’s Disease. Mov Disord. 2014;29(10):1273-1280. doi: 10.1002/mds.25961.esse

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Do not take XADAGO if you:

  • Take another medicine called monoamine oxidase inhibitors (MAOIs), as it could cause a sudden severe increase in your blood pressure.
  • Take an opioid drug, St. John’s wort, serotonin‐norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants, cyclobenzaprine, methylphenidate, amphetamine, or similar drugs because it could be life‐threatening.
  • Take a medicine used to treat a cough or cold called dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior.
  • Have a history of an allergic reaction to safinamide, as this can cause swelling of the tongue and mouth and trouble breathing.
  • Have severe liver disease. Do not exceed a dose of 50mg per day of XADAGO if you have moderate liver disease.

Before taking XADAGO, tell your healthcare provider about: All the medicines that you take or plan to take. Especially tell your healthcare provider if you take selective serotonin reuptake inhibitors (SSRIs), meperidine, methadone, propoxyphene, tramadol, or metoclopramide.

While taking XADAGO you should avoid: Certain foods and beverages that are high in tyramine such as aged, fermented, cured, smoked, and pickled foods. Do not drive, operate machinery, or work in high places or do other dangerous activities until you know how XADAGO affects you.

Possible serious side effects of XADAGO:

  • High blood pressure or make your high blood pressure worse. XADAGO may raise your blood pressure or make your high blood pressure worse. Possible symptoms of an unsafe rise in blood pressure include severe headache, blurred vision, confusion, seizures, shortness of breath, severe anxiety, and nausea and vomiting.
  • Serotonin syndrome. Potentially life‐threatening problem called serotonin syndrome can happen when taking XADAGO with certain other medicines. Symptoms may include agitation, hallucinations, coma, changes in mental status, seizures, problems controlling your movements or muscle twitching, sweating or fever, nausea or vomiting, fast heartbeat, muscle stiffness or tightness, or diarrhea.
  • Falling asleep during normal activities.
  • Uncontrolled, sudden movements (dyskinesia) or make such movements worse.
  • Hallucinations and other psychosis. XADAGO can cause or worsen symptoms of seeing or hearing things that are not real, confusion, agitation, delusional beliefs, and disorganized thinking.
  • Unusual urges or inability to control these urges.
  • Problems with retina in your eye (retinal changes). Tell your healthcare provider if your eyesight changes.

The most common side effects of XADAGO include:

Uncontrolled, sudden movements (dyskinesia), falls, nausea, trouble sleeping or falling asleep.

Please refer to the Medication Guide for additional important patient information.

INDICATION

  • XADAGO is a prescription medicine known as a monoamine oxidase type B (MAO‐B) inhibitor used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Please see full Prescribing Information and Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.